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The Tigers trailed 2-0 after three innings, but a seven-run fourth put the Tigers on top to stay.
Owen Golliher led the Tigers with three hits and three stolen bases, while Trent Weiss added a pair of hits.
Drew Pyle (1-1), who entered the game with one out in the fourth, picked up his first win of the season. He didn’t allow the Cardinals a hit the rest of the way, but did give up an unearned run.
The Tigers (2-1) visit Cowan for a doubleheader on Saturday.